2024 Pin1 mutant

Pin1 mutant

Author: ctxj

August undefined, 2024

WebPin1 is phosphorylated at S138 by mixed-lineage kinase 3 (MLK3) (Figure 1B) . The phosphorylation of S138 increases isomerase activity . The phosphorylation mimicking … WebJan 22, 2002 · A comparison of body weight of 10 wild-type and Pin1 −/− mutant male and female mice at ≈3.5 and ≈7 months is shown in B. (C and D) Testicular atrophy, as indicated by representative testis from wild-type or Pin1 −/− mouse at ≈3.5 months old (C) or by histopathological comparison (D). Testicular sections obtained from ≈3.5- and ...

National Center for Biotechnology Information

WebThe pin1-1 mutant of Arabidopsis thaliana has been pivotal for studies on auxin transport and on the role of auxin in plant development. It was reported previously that when whole … WebOct 15, 2004 · Single mutations in the PIN-FORMED1 ( PIN1) and PINOID ( PID )genes, which mediate auxin-dependent organ formation, moderately disrupt the symmetric … bowhead support email

Molecules Free Full-Text Dynamic Allostery Modulates …

WebJun 21, 2012 · When the pin1 mutant is combined with mutants in AUX1 and LAX1, the two proteins that are coexpressed with PIN1 in the L1 surface layer, the triple mutant … The gene encoding Pin1 was identified in 1996 as a result of a genetic/biochemical screen for proteins involved in mitotic regulation. It was found to be essential for cell division in some organisms. By 1999, however, it was apparent that Pin1 knockout mice had a surprisingly mild phenotype, indicating that the enzyme was not required for cell division per se. Further studies later found that loss of Pin1 in mice displays are not only neuronal degenerative phenotypes but … WebJun 1, 2024 · We demonstrate that Pin1 cooperates with mutant KRAS to promote transformation in PDAC, and that Pin1 inhibition impairs cell viability over time in PDAC cell lines. Main Proline-directed... bowhead springfield va

Requirement of the Auxin Polar Transport System in …

Pin1 mutant

PIN1-Independent Leaf Initiation in Arabidopsis Plant Physiology ...

WebJul 12, 2011 · If lowering PIN1 level is a contributing factor to phyllotactic perturbations in plt mutant combinations, PIN1 reduction alone should be sufficient to alter the phyllotactic … WebLoss of function severely affects organ initiation, pin1 mutants are characterised by an inflorescence meristem that does not initiate any flowers, resulting in the formation of a naked inflorescence stem. PIN1 is involved in the determination of leaf shape by actively promoting development of leaf margin serrations.

Did you know?

WebDec 22, 2009 · The PIN1 genes, fused to the green fluorescent protein (GFP) ( PIN1::PIN1-GFP) and the hemagglutinin (HA) ( PIN2::PIN1-HA ), were mutagenized and the constructs were transformed into the wild … WebDec 7, 2024 · We isolated one mutant line, SALK_122916c, as it was largely resistant to the inhibition effect of Torin2 on glucose-promoted primary root growth (Fig. 1 A and B). The …

WebOur results suggest that PIN1 plays a role in cancer cell proliferation, migration and invasion in a different manner according to the TP53 gene mutation status in HCC. In particular, interaction of PIN1 with mutant TP53 can act as a tumor promoter and increase its oncogenic activities in HCC. MeSH terms Adult WebAug 29, 2024 · A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell 20 , 79–91 (2011). Article PubMed CAS Google Scholar

WebAug 2, 2024 · PIN1 adopts a NhaA fold; this fold was first observed in the bacterial Na + /H + antiporter 27 and is shared by mammalian Na + /H + exchangers 28 and apical sodium-dependent bile acid transporter... WebJan 20, 2015 · When PIN1 is expressed under the control of the PIN2 promoter in the agravitropic pin2 mutant, it is, in contrast to PIN2, localized predominantly basally (toward root tip) in epidermis cells. Therefore, the auxin transport capacity in basipetal (shootward) direction, necessary for correct gravitropism, is not achieved.

WebPin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the antimetastatic factor p63 and induction of a mutant p53 transcriptional program to increase aggressiveness.

WebDec 7, 2024 · To exclude possible pleiotropic effects of T-DNA insertion, we examined another well-recognized PIN2 mutant, eir1-1 ( 7 ), and found that eir1-1, as compared to WT seedlings, was also less sensitive to Torin2-inhibited root growth ( Fig. 1 A and B ). Fig. 1. PIN2 is a key downstream regulator in glucose-TOR signaling. bowhead support group llcWebp53 protein is a well-known tumor suppressor factor that regulates cellular homeostasis. As it has several and key functions exerted, p53 is known as “the guardian of the genome” and either loss of function or gain of function mutations in the TP53 coding protein sequence are involved in cancer onset and progression. The Hippo pathway is a key regulator of … gulf shores al beachfront condoWebNov 4, 2013 · The agb1-2 single mutant also displayed increased basipetal auxin transport comparable to plants with downregulated NDL (Fig. 7A), which corresponds with the phenotypic data. Plants lacking AGB1 or with a sub-optimal level of NDL showed abnormally high auxin transport capacity. ... Polar auxin transport in shoots requires basally localized … bowhead support employee portalWebJan 27, 2016 · In the pin2 mutant, PIN1 was ectopically induced in the PIN2 expression domain in the cortex and epidermis with polarization, which PIN2 exhibited in these … gulf shores al catholic churchWebJun 17, 2013 · PIN1 down-regulation and pin1-5 mutation severely affect female gametophyte development since embryo sacs arrest at the mono- and/or bi-nuclear stages (FG1 and FG3 stage). PIN3 function is not required for ovule development in wild-type or PIN1 -silenced plants. bowhead support portalWebDec 31, 2024 · Phenotypic observations and statistics of HJ2 and different pin1 mutants. (a) Phenotypes of 7-day-old seedlings of HJ2, pin1c pin1d double mutant (pin1cd), pin1a pin1c pin1d triple mutant (pin1acd ... bowhead support password resetWebOct 13, 2024 · Abstract. The oncogenic transcription condition B-Myb is an essential regulator of slow cellphone cycle dna whose activation by phosphorylation is still poorly unders gulf shores al condos