2024 Tissue-specific genes

Tissue-specific genes

Author: qtbr

August undefined, 2024

WebApr 29, 2024 · In various mesoderm- and endoderm-derived tissues, genes in the GATA family play a critical role in adjusting tissue-specific gene expression (Kelley et al., 1993; Laverriere et al., 1994). The expression levels of toll-like receptors and some related genes, such as CD14, MyD88, and LY96, vary across different adult human tissues, including the ... WebThe adipose tissue-specific proteome. Adipose tissue (fat) is a highly specialized loose connective tissue mainly formed by adipocytes and has a number of physiological functions including the storage of energy and secretion of hormones such as leptin. Adipose tissue insulates and protects the organs. Fat is located around organs (visceral fat ...

The adipose tissue-specific proteome - Protein Atlas

WebMar 11, 2010 · Summary: The tissue-specific genes are a group of genes whose function and expression are preferred in one or several tissues/cell types. Identification of these … WebDRAB yielded biologically reasonable results and had sufficient power to detect genes with tissue-specific regulatory profiles while effectively controlling false positives. By providing a framework that facilitates the prioritization of differentially regulated genes, our study enables future discoveries on the genetic architecture of ... focused floor lamp

Genotype-Tissue Expression (GTEx) - National Institutes of Health

WebJul 27, 2011 · Background Categorizing protein-encoding transcriptomes of normal tissues into housekeeping genes and tissue-selective genes is a fundamental step toward studies of genetic functions and genetic associations to tissue-specific diseases. Previous studies have been mainly based on a few data sets with limited samples in each tissue, which … WebHumans and other eukaryotes are complex: we're made up of trillions of cells organized into unique tissues and body structures. Each cell in your body must run its own "program" of gene expression. Turning genes on in specific body parts Some genes need to be expressed in more than one body part or type of cell. WebAug 25, 2024 · This paper reports the cattle gene expression atlas, and links the tissue-specific gene expression to complex trait variation. Article Google Scholar The GTEx Consortium. The GTEx Consortium atlas ... focused flourishing in my lane

TiSGeD: a database for tissue-specific genes - PubMed

SUMOylation of Bonus, the Drosophila homolog of Transcription ...

WebBackground: Chemotherapy treatment of cancer in children can influence formation of normal tissues, leading to irreversible changes in their structure and function. Tooth formation is susceptible to several types of chemotherapy that induce irreversible changes in the structure of enamel, dentin and dental root morphology. These changes can make … WebOct 22, 2024 · While tools have been developed to identify biological processes that are enriched in the genes sets, there remains a need for tools that identify enrichment of tissue-specific genes.... focused flow through tax creditWebTissue-Specific Gene Expression. Specific pattern and level of expression of a transgene (Cre or Flp recombinase, reporter genes, safe harbour, target gene, etc.) are key … focused fluids

"WebDRAB yielded biologically reasonable results and had sufficient power to detect genes with tissue-specific regulatory profiles while effectively controlling false positives. By … " - Tissue-specific genes

Tissue-specific genes

A systematic survey of human tissue-specific gene expression …

Web1 hour ago · The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Drosophila only encodes one member of the family, Bonus. Bonus has been implicated in embryonic … WebJun 8, 2024 · There is likely a differential sensitivity to PARP inhibition based on the specific DDR gene altered, but research in this area is limited because of the low frequency of alterations in these genes. ... using next-generation sequencing (NGS) of tissue and plasma. ctDNA fraction correlates with radiographic and PSA response and is lower during ...

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WebRegarding expression patterns across tissues, genes can be positioned within a continuous scale that goes from housekeeping genes to tissue-specific genes. Housekeeping genes are responsible for critical cell functions and are ubiquitously expressed 1 , while tissue-specific genes are expressed in a single or a small subset of tissues ... WebNov 1, 2024 · Tissue-specific genes are defined using the algorithm from the HPA (Uhlén et al. 2015), and can be grouped as follows: Tissue Enriched: Genes with an expression level …

WebJul 1, 2024 · GTEx researchers used this method to identify specific genes associated with five diseases: bipolar disorder, coronary artery disease, Crohn's disease, rheumatoid … WebApr 30, 2024 · As utilities for drug discovery, we demonstrated that tissue-specificity is a highly desirable attribute of validated drug targets and tissue-specificity can be used to …

WebMay 14, 2024 · Tissue-Specific Knockout Mice While "housekeeping" genes are expressed in all types of cells at all stages of development, other genes are normally expressed in only certain types of cells when turned on by the appropriate signals (e.g. the arrival of a hormone). To study such genes, one might expect that the methods described above … WebOct 3, 2024 · Assessing the tissue-specificity of these trends on a per-gene basis we found that while the estimated heritability of gene expression tended to be similar among different tissues, the...

WebJun 23, 2024 · We report a comprehensive list of tissue-specific genes across 17 tissues, along with a list of 4,781 housekeeping genes in mouse. In addition, we propose a list of 27 consistently and highly expressed genes that can be used as reference controls in expression-profiling analysis. Our study provides a unique resource of mouse gene …

http://www.gen-info.osaka-u.ac.jp/~uhmin/study/others/tissue_specific/ focused folder outlookWebTissue-specific genes are only expressed in certain cell types. In cell types in which these genes are not expressed, the CpG island near the promoter is fully methylated. In cell types in which the gene is expressed, the CpG island near the promoter is unmethylated. As a final example, the inactive X chromosome (Barr body) in female mammals ... focused focusingWebThe Human Tissue Specific Proteome Tissue elevated genes Group enriched proteins Relevant links and publications The Human Tissue Specific Proteome All, approximately … focused forensic solutionsWebThe GTEx (Genotype-Tissue Expression) Consortium has established a reference catalogue and associated tissue biobank for gene-expression levels across individuals for diverse … focused foreverWebThe tissue section - Tissue-based map of the human proteome. This section of the Human Protein Atlas focuses on the expression profiles in human tissues of genes both on the … focused forensicWebAug 23, 2024 · Tissue-specific genes are a class of genes that are highly expressed in specific tissues and play a role in transcriptional regulation, development, stress response, and even disease development (34–36). Therefore, the study of brain-specific genes is conducive to comprehensively understanding the function and mechanism of mood … focused for bowlingWebNov 25, 2024 · Strictly, tissue-specific genes refer to genes whose function and expression are limited to specific tissue or cell types. In many cases, however, the concept of … focused fork